COMPARTMENTS

Subcellular localization database

POGLUT1 localizations

POGLUT1 [ENSP00000295588]

Myelodysplastic syndromes relative protein; Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C. Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2. Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development. Notch glucosylation does not affect Notch ligand binding. Required during early development to promote gastrulation: acts by mediating O- glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity).

Synonyms:  POGLUT1,  POGLUT1p,  hPOGLUT1,  B4DJ97,  B4DVA9 ...

Linkouts:  STRING  Pharos  UniProt

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence