(E3-independent) E2 ubiquitin-conjugating enzyme E1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination; Belongs to the ubiquitin-conjugating enzyme family.
Synonyms: UBE2E1, UBE2E1p, hUBE2E1, A0A024R2K3, B7Z306 ...