COMPARTMENTS

Subcellular localization database

SIK2 localizations

SIK2 [ENSP00000305976]

Serine/threonine-protein kinase SNF1-like kinase 2; Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Synonyms:  SIK2,  SIK2p,  hSIK2,  A0A024R3G7,  Q9H0K1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence