Adipose-specific phospholipase A2; Lipid-modifying enzyme that acts as major regulator of adipocyte lipolysis by catalyzing the release of fatty acids from phospholipids in adipose tissue. Shows phospholipase A1 and A2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, phospholipase A1 activity is much higher than phospholipase A2 activity. Phospholipase activity causes decreased intracellular levels of ether-type lipids, affecting peroxisome metabolism (By similarity). May also have acyltransferase activity: catalyzes both N-acylation of phosphatidylethanolamine to form N-acyl-phosphatidylethanolamine and O-acylation of lyso-phosphatidylcholines to form phosphatidylcholines. The relevance of acyltransferase activity in vivo is however unclear and would require additional evidences. Also has weak lysophospholipase activity (By similarity); Belongs to the H-rev107 family.
Synonyms: PLA2G16, PLA2G16p, hPLA2G16, A0A024R561, F5H7E5 ...