COMPARTMENTS

Subcellular localization database

NFAM1 localizations

NFAM1 [ENSP00000333680]

Calcineurin/NFAT-activating ITAM-containing protein; May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross- linking.

Synonyms:  NFAM1,  NFAM1p,  hNFAM1,  F8WE95,  Q8NET5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence