COMPARTMENTS

Subcellular localization database

LRRC8D localizations

LRRC8D [ENSP00000338887]

Leucine rich repeat containing 8 family, member D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. LRRC8A and LRRC8D are required for the uptake of the drug cisplatin. Mediates the import of the antibiotic blasticidin-S into the cell.

Synonyms:  LRRC8D,  LRRC8Dp,  hLRRC8D,  DKFZP547I0910,  DKFZP666L2010 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence