COMPARTMENTS

TRIM29 [ENSP00000343129]

Tripartite motif-containing protein 29; Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.

Synonyms:  TRIM29,  TRIM29p,  hTRIM29,  A0A024R3J1,  E9PI31 ...

Linkouts:  STRING  Pharos  UniProt  OMIM