Astacin-like metallo-endopeptidase (M12 family); Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity); Belongs to the peptidase M12A family.
Synonyms: ASTL, Q6HA08, Q6HA08p, hQ6HA08, 3.4.-.- ...