114 kDa Rho-specific guanine nucleotide exchange factor; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells; Pleckstrin homology domain containing
Synonyms: ARHGEF18, ARHGEF18-001, ARHGEF18-002, ARHGEF18-003, ARHGEF18-005 ...