Subcellular localization database

PRKACB localizations

PRKACB [ENSP00000359719]

cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis . Phosphorylates GPKOW which regulates its ability to bind RNA . ; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

Synonyms:  PRKACB,  A0A087WVC4,  A0A0A0MS54,  B1APF7,  B1APF8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence