AGO4 localizations
AGO4 [ENSP00000362306]
Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). ; Belongs to the argonaute family. Ago subfamily.
Synonyms: AGO4, AGO4p, hAGO4, Q9HCK5, Q9HCK5p ...
Linkouts: STRING Pharos UniProt
Knowledge
| Name | Source | Evidence | Confidence |
|---|---|---|---|
| RISC-loading complex | BHF-UCL | IDA | ★★★★☆ |
| RISC complex | BHF-UCL | IDA | ★★★★☆ |
| Cytoplasmic ribonucleoprotein granule | HPA | IDA | ★★★★☆ |
| Cytoplasm | BHF-UCL | IDA | ★★★★☆ |
| Cytosol | HPA | IDA | ★★★★☆ |
| Membrane | UniProtKB | HDA | ★★★★☆ |
| Nucleus | GO_Central | IBA | ★★★☆☆ |
| P-body | UniProtKB-SubCell | IEA | ★★★☆☆ |
Fetching ...
Predictions
| Name | Source | Evidence | Confidence |
|---|---|---|---|
| Nucleus | YLoc | 99.9% | ★★★☆☆ |
| Nucleus | PSORT | 16/32 | ★★☆☆☆ |
| Cytosol | PSORT | 11.5/32 | ★★☆☆☆ |
| Plasma membrane | PSORT | 6.5/32 | ★☆☆☆☆ |
| Lysosome | PSORT | 1/32 | ★☆☆☆☆ |
| Mitochondrion | PSORT | 1/32 | ★☆☆☆☆ |
| Extracellular region | PSORT | 1/32 | ★☆☆☆☆ |
| Peroxisome | PSORT | 1/32 | ★☆☆☆☆ |