COMPARTMENTS

Subcellular localization database

LIG3 localizations

LIG3 [ENSP00000367787]

Polydeoxyribonucleotide synthase [ATP] 3; Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand- break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair.

Synonyms:  LIG3,  LIG3p,  hLIG3,  B7Z6I3,  C4B7Q3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence