COMPARTMENTS

Subcellular localization database

ATG16L1 localizations

ATG16L1 [ENSP00000375872]

Autophagy related 16-like 1 (S. cerevisiae); Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production. Negatively regulates NOD1- and NOD2- driven inflammatory cytokine response. Plays a role in regulating morphology and function of Paneth cell; Belongs to the WD repeat ATG16 family.

Synonyms:  ATG16L1,  ATG16L1p,  hATG16L1,  A0A024R494,  A0A024R4B6 ...

Linkouts:  STRING  Pharos

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence