COMPARTMENTS

Subcellular localization database

CTDSP2 localizations

CTDSP2 [ENSP00000381148]

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2; Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas; CTD family phosphatases

Synonyms:  CTDSP2,  CTDSP2p,  hCTDSP2,  A0A024RB65,  A0A024RBA6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence