COMPARTMENTS

Subcellular localization database

SIAH3 localizations

SIAH3 [ENSP00000383256]

Siah E3 ubiquitin protein ligase family member 3; Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria.

Synonyms:  SIAH3,  SIAH3p,  hSIAH3,  Q8IW03,  Q8IW03p ...

Linkouts:  STRING  Pharos  UniProt  OMIM

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence