Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL- 4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons; Nuclear factors of activated T-cells
Synonyms: NFATC4, NFATC4p, hNFATC4, G3V4K1, G3V4U6 ...