Subcellular localization database

PLEKHF1 localizations

PLEKHF1 [ENSP00000389787]

Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains; May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase- independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8; Pleckstrin homology domain containing

Synonyms:  PLEKHF1,  PLEKHF1p,  hPLEKHF1,  B4DWN9,  K7EIX0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence