COMPARTMENTS

Subcellular localization database

EWSR1 localizations

EWSR1 [ENSP00000400142]

Ewing sarcoma breakpoint region 1 protein; Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes; Belongs to the RRM TET family.

Synonyms:  EWSR1,  EWSR1p,  hEWSR1,  B0QYJ3,  B0QYJ4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence