TRAMP-like complex RNA-binding factor ZCCHC8; Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non- coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor SKIV2L2/MTR4, which links to RNA-binding protein adapters. May be involved in pre-mRNA splicing (Probable).
Synonyms: ZCCHC8, ZCCHC8p, hZCCHC8, F5GX80, F5GXQ6 ...