COMPARTMENTS

Subcellular localization database

APAF1 localizations

APAF1 [ENSP00000448165]

Apoptotic peptidase activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis; Apoptosome

Synonyms:  APAF1,  APAF1p,  hAPAF1,  C9JLV4,  F8VNZ0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence