Nuclear factor of activated T-cells 5, tonicity-responsive; Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity. Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17. Binds the DNA consensus sequence 5'- [ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3'; Nuclear factors of activated T-cells
Synonyms: NFAT5, NFAT5p, hNFAT5, A0A024R734, F6X8W2 ...