NOSIP localizations
NOSIP [ENSP00000470034]
Nitric oxide synthase interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family.
Synonyms: NOSIP, M0QX85, M0R1K2, M0R1T7, M0R3B2 ...