ORAI1 localizations
ORAI1 [ENSP00000480616]
Calcium release-activated calcium channel protein 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT; Belongs to the Orai family.
Synonyms: ORAI1, ORAI1p, hORAI1, A0A024RBT3, F5GWZ3 ...