COMPARTMENTS

Subcellular localization database

SOCS7 localizations

SOCS7 [ENSP00000482229]

Nck, Ash and phospholipase C gamma-binding protein; Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF- like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity); SH2 domain containing

Synonyms:  SOCS7,  SOCS7p,  hSOCS7,  J9JID8,  J9JID8p ...

Linkouts:  STRING  Pharos

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence