GCKR localizations
GCKR [ENSP00000264717]
Glucokinase regulatory protein; Regulates glucokinase (GCK) by forming an inactive complex with this enzyme . Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal . The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity .
Synonyms: GCKR, A0A0C4DFN2, H7C1B4, H7C4D3, Q14397 ...