COMPARTMENTS

GRN [ENSP00000053867]

Paragranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:28541286, PubMed:28073925, PubMed:18378771, PubMed:28453791, PubMed:12526812). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes . Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB . In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases . Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity . ECO:0000269|PubMed:18378771, ECO:0000269|PubMed:28073925, [Granulin-3]: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8.

Synonyms:  GRN,  K7EJY4,  K7EK92,  K7EKL3,  K7ELY1 ...

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