COMPARTMENTS

TNFRSF1A [ENSP00000162749]

Tumor necrosis factor receptor superfamily member 1A, membrane form; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

Synonyms:  TNFRSF1A,  F5GWJ4,  F5H061,  F5H4T5,  F5H6V7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM