RIPK3 localizations
RIPK3 [ENSP00000216274]
Receptor-interacting serine/threonine-protein kinase 3; Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439,; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Synonyms: RIPK3, RIPK3p, hRIPK3, H0YJN5, Q9Y572 ...
Linkouts: STRING Pharos UniProt OMIM
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