COMPARTMENTS

GZMB [ENSP00000216341]

Granzyme B; This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis; Belongs to the peptidase S1 family. Granzyme subfamily.

Synonyms:  GZMB,  E9PID1,  E9PLX4,  E9PRD7,  J3KPK2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM