COMPARTMENTS

PSMD10 [ENSP00000217958]

26S proteasome non-ATPase regulatory subunit 10; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.

Synonyms:  PSMD10,  PSMD10p,  hPSMD10,  B1AJY5,  B1AJY6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM