COMPARTMENTS

IL23A [ENSP00000228534]

Interleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Synonyms:  IL23Ap,  hIL23A,  Q9NPF7,  Q9NPF7p,  hQ9NPF7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM