COMPARTMENTS

AHR [ENSP00000242057]

Aryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates (PubMed:10395741, PubMed:28602820, PubMed:7961644, PubMed:23275542, PubMed:30373764). Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) . Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons . Involved in cell-cycle regulation . Likely to play an important role in the development and maturation of many tissues . Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 . Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription . ECO:0000269|PubMed:28602820, ECO:0000269|PubMed:30373764,

Synonyms:  A0A024R9Z8,  A0A2R8Y7G1,  P35869,  P35869p,  hP35869 ...

Linkouts:  STRING  Pharos  UniProt  OMIM