MKRN1 localizations
MKRN1 [ENSP00000255977]
E3 ubiquitin-protein ligase makorin-1; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II- dependent transcription.
Synonyms: MKRN1, MKRN1p, hMKRN1, C9IY57, C9IZP5 ...
Linkouts: STRING Pharos UniProt OMIM
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