COMPARTMENTS

DUSP26 [ENSP00000256261]

Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).

Synonyms:  DUSP26,  DUSP26p,  hDUSP26,  E5RHD0,  Q9BV47 ...

Linkouts:  STRING  Pharos  UniProt