NOTCH2 localizations
NOTCH2 [ENSP00000256646]
Neurogenic locus notch homolog protein 2; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation . Positively regulates self-renewal of liver cancer cells . ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737,
Synonyms: NOTCH2, NOTCH2p, hNOTCH2, A0A1W2PQQ5, A0A494C049 ...
Linkouts: STRING Pharos UniProt OMIM
Fetching ...
Fetching ...
Fetching ...