GDF11 localizations
GDF11 [ENSP00000257868]
Growth/differentiation factor 11; Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 ; Belongs to the TGF-beta family.
Synonyms: GDF11, GDF11p, hGDF11, A0A024RB20, H0YI30 ...
Linkouts: STRING Pharos UniProt OMIM
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