USP14 localizations
USP14 [ENSP00000261601]
Ubiquitin carboxyl-terminal hydrolase 14; Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation. ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427,; Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
Synonyms: USP14, USP14p, hUSP14, A6NJA2, J3KS55 ...
Linkouts: STRING Pharos UniProt OMIM
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