COMPARTMENTS

CDH1 [ENSP00000261769]

Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins . They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells . Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria.

Synonyms:  CDH1,  CDH1p,  hCDH1,  A0A087WU43,  A0A087WX17 ...

Linkouts:  STRING  Pharos  UniProt  OMIM