COMPARTMENTS

PTPN4 [ENSP00000263708]

Tyrosine-protein phosphatase non-receptor type 4; Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis . Regulates neuronal cell homeostasis by protecting neurons against apoptosis . Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction . Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (By similarity). May act at junctions between the membrane and the cytoskeleton. ECO:0000250|UniProtKB:Q9WU22, ECO:0000269|PubMed:20086240,; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily.

Synonyms:  PTPN4,  PTPN4p,  hPTPN4,  A0A024RAE8,  F5H020 ...

Linkouts:  STRING  Pharos  UniProt  OMIM