COMPARTMENTS

PDCL3 [ENSP00000264254]

Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation . Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding . Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis . ECO:0000269|PubMed:17429077, ECO:0000269|PubMed:23792958,

Synonyms:  PDCL3,  PDCL3p,  hPDCL3,  C9JST4,  H7BZP2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM