COMPARTMENTS

SLC27A2 [ENSP00000267842]

Very long-chain acyl-CoA synthetase; Acyl CoA synthetase that activates long-chain and very long- chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl- CoA . Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid . Does not activate C24 bile acids, cholate and chenodeoxycholate . In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol . Exhibits long-chain fatty acids (LCFA) transport activity and plays an important role in hepatic fatty acid uptake . ECO:0000269|PubMed:10749848, ECO:0000269|PubMed:11980911, Isoform 2 exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids.

Synonyms:  SLC27A2,  SLC27A2p,  hSLC27A2,  G3V1R7,  O14975 ...

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