COMPARTMENTS

IRF8 [ENSP00000268638]

Interferon regulatory factor 8; Plays a role as a transcriptional activator or repressor . Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Positively regulates macroautophagy in dendritic cells .

Synonyms:  IRF8,  IRF8p,  hIRF8,  H3BNX4,  H3BPS5 ...

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