GAS8 localizations
GAS8 [ENSP00000268699]
Dynein regulatory complex subunit 4; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning . Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (By similarity). ECO:0000250|UniProtKB:Q7XJ96, ECO:0000269|PubMed:26387594,
Synonyms: GAS8, GAS8p, hGAS8, A0A087WZT7, A0A384MR00 ...
Linkouts: STRING Pharos UniProt OMIM
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