COMPARTMENTS

TM4SF5 [ENSP00000270560]

Transmembrane 4 L6 family member 5; Acts as a lysosomal membrane arginine sensor . Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations . Facilitates cell cycle G1/S phase progression and the translocation of the CDK4- CCND1 complex into the nucleus . CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression ; Belongs to the L6 tetraspanin family.

Synonyms:  TM4SF5,  TM4SF5p,  hTM4SF5,  O14894,  O14894p ...

Linkouts:  STRING  Pharos  UniProt  OMIM