FNBP1L localizations
FNBP1L [ENSP00000271234]
Formin-binding protein 1-like; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens; Belongs to the FNBP1 family.
Synonyms: FNBP1L, FNBP1Lp, hFNBP1L, A0A075B6Q2, Q5T0N5 ...
Linkouts: STRING Pharos UniProt OMIM
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