SHPRH localizations
SHPRH [ENSP00000275233]
E3 ubiquitin-protein ligase SHPRH; E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly- ubiquitin chains linked through 'Lys-63'; Belongs to the SNF2/RAD54 helicase family.
Synonyms: SHPRH, A0A0D9SFM0, H0YBI0, H7C2W2, K4DI94 ...
Linkouts: STRING Pharos UniProt OMIM
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