JADE2 localizations
JADE2 [ENSP00000282605]
E3 ubiquitin-protein ligase Jade-2; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo . Acts as a E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A . Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity).
Synonyms: JADE2, JADE2p, hJADE2, A0A087X085, A0A0C4DFT8 ...