FGD5 localizations
FGD5 [ENSP00000285046]
FYVE, RhoGEF and PH domain-containing protein 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF- induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
Synonyms: FGD5, FGD5p, hFGD5, A0A1W2PRG7, A0A2X0SFF2 ...
Linkouts: STRING Pharos UniProt OMIM
Knowledge
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| Name | Source | Evidence | Confidence |
|---|---|---|---|
| COP9 signalosome | UniProtKB | IDA | ★★★★★ |
| Nucleoplasm | HPA | IDA | ★★★★☆ |
| Nucleoplasm | HPA | IDA | ★★★★☆ |
| Cytosol | HPA | IDA | ★★★★☆ |
| Nucleoplasm | HPA | IDA | ★★★★☆ |
| Cytoplasm | ComplexPortal | IDA | ★★★★☆ |
| Nucleus | ComplexPortal | IDA | ★★★★☆ |
| Nucleoplasm | HPA | IDA | ★★★★☆ |
| Nucleoplasm | HPA | IDA | ★★★★☆ |
| Cytosol | HPA | IDA | ★★★★☆ |
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Predictions
| Name | Source | Evidence | Confidence |
|---|---|---|---|
| Cytosol | YLoc | 97.1% | ★★☆☆☆ |
| Nucleus | PSORT | 14/32 | ★★☆☆☆ |
| Cytosol | PSORT | 11/32 | ★★☆☆☆ |
| Peroxisome | PSORT | 3/32 | ★☆☆☆☆ |
| Extracellular region | PSORT | 2/32 | ★☆☆☆☆ |
| Mitochondrion | PSORT | 2/32 | ★☆☆☆☆ |