COMPARTMENTS

ZYG11B [ENSP00000294353]

Protein zyg-11 homolog B; Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZER1 to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N- myristoylation .

Synonyms:  ZYG11B,  ZYG11Bp,  hZYG11B,  A8DPD7,  Q9C0D3 ...

Linkouts:  STRING  Pharos  UniProt