TDGF1 localizations
TDGF1 [ENSP00000296145]
Teratocarcinoma-derived growth factor 1; GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells . Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm .
Synonyms: TDGF1, TDGF1p, hTDGF1, F5H1T8, P13385 ...
Linkouts: STRING Pharos UniProt OMIM
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